کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2124458 1547256 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of a novel, functional role for S100A13 in invasive lung cancer cell lines
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Identification of a novel, functional role for S100A13 in invasive lung cancer cell lines
چکیده انگلیسی
Depletion of cellular S100A13 mRNA levels by RNAi in highly invasive lung cancer cell lines resulted in a 50-80% decrease in their invasive potential in an in vitro assay. This reduction could not be accounted for by reduced cellular proliferation. Conversely, transient overexpression of exogenous S100A13 in less invasive cell lines had no impact on invasive potential suggesting that upregulation of S100A13 expression alone is insufficient to induce the phenotype. We conclude that S100A13 is involved in but not capable of inducing invasion, since elevated S100A13 mRNA expression correlates with a more invasive phenotype and in vitro invasion can be inhibited by reduced S100A13 expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 44, Issue 1, January 2008, Pages 151-159
نویسندگان
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