کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2124818 | 1547278 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Influence of familial cancer history on lymphoid neoplasms risk validated in the large European case-control study epilymph
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Lymphomas have a potentially important familial component; large studies using recent classification systems are lacking. Based on a multicentre case-control study in seven European countries, we recruited 2480 cases of lymphoid neoplasms (LN) and 2540 controls, matched by country, age and sex. Diagnoses were established according to the World Health Organisation (WHO) classification. We estimated odds ratios (OR) and 95% confidence intervals (CI) for cancer in first-degree relatives and for the kind of relative affected. The OR of LN for a family history of haematological cancer was 1.6 (ORÂ =Â 1.2-2.1). The OR was particularly high for chronic lymphocytic leukaemia (CLL) (ORÂ =Â 2.9 [1.9-4.5]). A familial case of lymphoma increased the risk of Hodgkin's lymphoma (HL) (ORÂ =Â 3.4 [1.5-7.8]). No increased risk was observed for diffuse large B-cell and follicular lymphomas. For CLL and HL, the risk was similar in parents, offspring and siblings. Our study suggests familial aggregation of CLL with a family history of haematological cancer and of HL with a family history of lymphoma. The transmission pattern suggests a dominant model of heredity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 42, Issue 15, October 2006, Pages 2570-2576
Journal: European Journal of Cancer - Volume 42, Issue 15, October 2006, Pages 2570-2576
نویسندگان
Romain Casey, Paul Brennan, Nikolaus Becker, Paolo Boffetta, Pierluigi Cocco, Eva Domingo-Domenech, Lenka Foretova, Alexandra Nieters, Silvia de Sanjosé, Anthony Staines, Martine Vornanen, Marc Maynadié,