کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2125343 1547226 2009 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Superficial soft tissue sarcomas (S-STS): A study of 367 patients from the French Sarcoma Group (FSG) database
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Superficial soft tissue sarcomas (S-STS): A study of 367 patients from the French Sarcoma Group (FSG) database
چکیده انگلیسی

AimThe specific natural history of superficial soft tissue sarcomas (S-STS) has been rarely considered. We describe the clinical characteristics of a large series of S-STS (N = 367) from the French Sarcoma Group (GSF-GETO) database and analyse the prognostic factors affecting outcome.MethodsWe performed univariate and multivariate analyses for overall survival (OS), metastasis-free survival (MFS) and local recurrence-free survival (LRFS).ResultsThe median age was 59 years. Fifty-eight percent patients were female. Tumour locations were as follows: extremities, 55%; trunk wall, 35.4%; head and neck, 8% and unknown, 1.6%. Median tumour size was 3.0 cm. The most frequent tumour types were unclassified sarcoma (24.3%) and leiomyosarcoma (22.3%). Thirty-three percent of cases were grade 3. Median follow-up was 6.18 years. The 5-year OS, MFS and LRFS rates were 80.9%, 80.7% and 74.7%, respectively. Multivariate analysis retained histological type and wide resection for predicting LRFS and histological type and grade as prognostic factors of MFS. The factors influencing OS were age, histological type, grade and wide resection. STS with early invasion into but not through the underlying fascia had a significantly poorer MFS than with strict S-STS.ConclusionS-STS represent a separate category characterised by a better outcome. Adequate surgery, i.e. wide resection, is essential in the management of S-STS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 45, Issue 12, August 2009, Pages 2091–2102
نویسندگان
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