کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2125514 | 1547234 | 2009 | 8 صفحه PDF | دانلود رایگان |
Mannose-binding lectin (MBL)-deficient children with cancer may benefit from substitution of the innate immune protein MBL during chemotherapy-induced neutropaenia. We determined the safety and pharmacokinetics of MBL substitution in a phase II study in MBL-deficient children.Twelve MBL-deficient children with cancer (aged 0–12 years) received infusions of plasma-derived MBL once, or twice weekly during a chemotherapy-induced neutropaenic episode (range: 1–4 weeks). Four patients participated multiple times. Target levels of 1.0 μg/ml were considered therapeutic.In total, 65 MBL infusions were given. No MBL-related adverse reactions were observed, and the observed trough level was 1.06 μg/ml (range: 0.66–2.05 μg/ml). Pharmacokinetics were not related to age after correction for body weight. The half-life of MBL, for a child of 25 kg, was 36.4 h (range: 23.7–66.6 h). No anti-MBL antibodies were measured 4 weeks after each MBL course.Substitution therapy with MBL-SSI twice weekly was safe and resulted in trough levels considered protective.
Journal: European Journal of Cancer - Volume 45, Issue 4, March 2009, Pages 505–512