کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2125834 1645487 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Systematic review of the association between circulating interleukin-6 (IL-6) and cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Systematic review of the association between circulating interleukin-6 (IL-6) and cancer
چکیده انگلیسی

Our aim was to systematically review the epidemiologic evidence for an association of circulating interleukin-6 (IL-6), an inflammatory cytokine and cancer. We systematically searched electronic databases Embase, Medline and Web of Science for the studies of circulating IL-6 and any form of cancer. We identified and reviewed 189 discrete studies, consisting of 177 prevalent studies and three prospective studies. Cancer patients’ IL-6 concentrations were higher than healthy controls’ in most studies, but the results of investigations comparing IL-6 in cancer patients and individuals with benign diseases were less consistent. Due to the small number of prospective studies it is impossible to determine whether IL-6 is causally related to cancer. Large prospective studies of circulating IL-6 or studies using the functional variants of the IL-6 gene as instruments for circulating IL-6 concentrations would provide information on possible aetiological links between IL-6 and malignancy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 44, Issue 7, May 2008, Pages 937–945
نویسندگان
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