کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2126138 | 1547290 | 2006 | 5 صفحه PDF | دانلود رایگان |

To estimate the risk of venous thrombosis associated with pancreatic malignancies we followed a cohort of patients with pancreatic cancer (n = 202). We calculated incidence rates of venous thrombosis and compared this with population rates using a Standardised Morbidity Ratio (SMR). The effects of location, histology and treatment were assessed by Cox-modelling. The incidence of venous thrombosis was 108.3/1000 patient-years (95% confidence interval (CI) 64.4–163.8), 58.6-fold increased (SMR 58.6, 95% CI 36.9–92.9). Patients with a tumour of the corpus/cauda had a 2-fold increased risk compared with those with a tumour of the caput. Patients treated with chemotherapy had a 4.8-fold increased risk (HRadj 4.8, 95% CI 1.1–20.8), whereas radiotherapy did not increase the risk. In a postoperative period of 30 d, patients had a 4.5-fold increased risk of venous thrombosis (HRadj 4.5, 95% CI 0.5–40.9). The risk was 1.9-fold increased in the presence of distant metastases (HRadj 1.9, 95% CI 0.7–5.1). Anti-thrombotic prophylaxis seems warranted in the first month after surgery, during and after treatment with chemotherapy, and when distant metastases have been diagnosed.
Journal: European Journal of Cancer - Volume 42, Issue 3, February 2006, Pages 410–414