کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2126318 | 1547282 | 2006 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Multiple myeloma: Monoclonal antibodies-based immunotherapeutic strategies and targeted radiotherapy Multiple myeloma: Monoclonal antibodies-based immunotherapeutic strategies and targeted radiotherapy](/preview/png/2126318.png)
Multiple myeloma (MM) is an incurable B-cell malignancy of terminally differentiated plasma cells. Besides conventional treatments, several targeted therapies are emerging for MM. We review recent developments in monoclonal antibodies (MoAbs) and (radio)immunoconjugates-based targeted immunotherapeutic (serotherapies) strategies, as well as skeletal targeted radiotherapy (STR™) in MM. MoAbs-based strategies include the targeting of cytokines and their receptors as well as toxins, drugs or radionuclide delivery to MM cells. Both targeted radioimmunotherapy (RIT) and STR™ have proved efficient in the treatment of radiosensitive tumours. We conclude that there is a need for more mechanistic investigations of drug action to identify novel therapeutic targets in myeloma cells, as well as in the bone marrow microenvironment.
Journal: European Journal of Cancer - Volume 42, Issue 11, July 2006, Pages 1640–1652