کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2126460 | 1547293 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Placenta growth factor is over-expressed and has prognostic value in human breast cancer
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کلمات کلیدی
Angiogenesis - آنژیوژنزImmunohistochemistry - ایمونوهیستوشیمیBreast cancer - سرطان پستانplacenta growth factor - عامل رشد جفتVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیreal-time quantitative polymerase chain reaction - واکنش زنجیره ای پلیمراز کمی زمان واقعی استprognosis - پیش شناخت بیماریvascular endothelial growth factor receptor-1 - گیرنده 1 فاکتور رشد اندوتلیال عروقی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Placenta growth factor (PlGF) belongs to the vascular endothelial growth factor (VEGF) family, a group of angiogenic factors that are crucial for tumour angiogenesis. Very little is known about the significance of PlGF in human cancer. We hypothesise that PlGF may have a potent influence in breast cancer. This study examined PlGF levels in human breast cancer in relation to patient's clinical parameters. PlGF expression and distribution was examined quantitatively using real-time quantitative polymerase chain reaction (Q-PCR) on a cohort of human breast cancer tissue (n = 119) and background breast tissue (n = 33), qualitatively using reverse transcriptase polymerase chain reaction (RT-PCR) on a range of cell lines, and immunohistochemically on patient samples. All these techniques revealed that PlGF expression was dramatically increased (P = 0.028) in breast cancer tissues compared with normal breast tissue. We demonstrate that PlGF displays prognostic value through analysis of patient survival status (6-year follow-up), as elevated levels of PlGF were significantly associated (P = 0.017) with recurrence, metastasis and patient mortality. Our study has shown that PlGF is over-expressed in breast cancer tissues and correlates with patient prognosis, and is likely to play a major role in the pathogenesis of tumours.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 41, Issue 18, December 2005, Pages 2819-2827
Journal: European Journal of Cancer - Volume 41, Issue 18, December 2005, Pages 2819-2827
نویسندگان
Christian Parr, Gareth Watkins, Mike Boulton, Jun Cai, Wen G. Jiang,