Snail transcription factors in hematopoietic cell development: A model of functional redundancy

Coordinated gene expression is crucial in facilitating proper lymphoid cell development and function. The precise patterns of gene expression during B- and T-cell development are regulated through a complex interplay between a multitude of transcriptional regulators, both activators and repressors. We have recently identified the Snail family of transcription factors as playing significant and overlapping roles in lymphoid cell development, in that deletion of both SNAI2 and SNAI3 was required to fully impact the generation of mature T and B cells. Analyses using compound heterozygote animals further demonstrated that SNAI2 and SNAI3 were partially haplosufficient and relatively equivalent in their ability to preserve B-cell generation in the bone marrow. In this review, we summarize studies elucidating the role of the Snail family in hematopoiesis, with a focus on lymphoid cell development. Using the Snail family as an example, we discuss the concepts of functional redundancy and strategies employed to assay transcription factor families for intramember compensation.