کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2133438 | 1087405 | 2016 | 9 صفحه PDF | دانلود رایگان |
• Hematopoietic stem/progenitor cells contribute to blood supply during infection.
• Cytokines, pathogen-associated molecular patterns, and niche cells coordinately regulate the fate decision of hematopoietic stem/progenitor cells.
• The c-di-GMP/STING pathway attenuates hematopoietic stem cell function and mobilizes hematopoietic stem/progenitor cells.
Hematopoietic stem/progenitor cells (HSPCs) play important roles in fighting systemic infection as they supply immune cells in a demand-adapted manner. Various mechanisms govern HSPC responses to infection, including cytokine signaling, niche function, and direct sensing of pathogen-derived molecules by HSPCs themselves. Here we review recent advances in our understanding of HSPC responses to infection and also consider newly identified STING-mediated machinery recognizing bacteria-derived cyclic dinucleotides.
Journal: - Volume 44, Issue 2, February 2016, Pages 92–100