Internal tandem duplication of Flt3 modulates chemotaxis and survival of hematopoietic cells by SDF1α but negatively regulates marrow homing in vivo

Our results suggest that functional interactions between Flt3 and SDF1α/CXCR4 regulate oncogenic proliferation and migration of hematopoietic cells, which is mediated by Ras, and that Flt3 signaling regulates hematopoietic cell trafficking in vivo.