Iron/IRP-1-dependent regulation of mRNA expression for transferrin receptor, DMT1 and ferritin during human erythroid differentiation

ObjectiveWe investigated iron regulatory protein (IRP)-dependent expression of transferrin receptor (TfR), divalent metal transpoter-1 (DMT1) and ferritin during erythroid differentiation system using an in vitro three-phase liquid culture.MethodPeripheral blood hematopoietic progenitor cells were cultured with interleukin-3 and stem cell factor