Future directions for bone metastasis research – highlights from the 2015 bone and the Oncologist new updates conference (BONUS)

• Due to reduced funding, performing bone metastasis-related research is increasingly challenging.
• The BONUS 2015 meeting identified 3 important themes for future bone metastasis-related studies.
• Is bone metastases-related pain the main issue facing patients?
• Are there new therapeutic targets for patients with bone metastases?
• How do we more firmly link basic science with clinical practice?

In an era of reduced peer-reviewed grant funding, performing academic bone oncology-related research has become increasingly challenging. Over the last 10 years we have held an annual meeting to bring together clinicians, clinician/scientists and basic biomedical researchers interested in the effects of cancer and its treatment on skeletal tissues. In the past these “Bone and the Oncologist New Updates Conference (BONUS)” meetings have served as critical catalyst for initiating productive research collaborations between attendees. The 2015 BONUS meeting format focused on potential key research themes that could form the basis of a coordinated national research strategy to tackle unmet clinical and research needs related to complications associated with cancer metastasis to bone. The three themes planned for discussion were: Is bone metastases-related pain the main issue facing patients? Are there new therapeutic targets for patients with bone metastases? How do we more firmly link basic science with clinical practice? We present a summary of lectures and commentaries from the attendees to serve as an example that other similarly motivated groups can model and share their experiences. It is our hope that these presentations will result in comments, feedback and suggestions from all those researchers interested in this important area.