کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2136962 1087827 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lack of association between TNF-α promoter polymorphisms and multiple myeloma: A meta-analysis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Lack of association between TNF-α promoter polymorphisms and multiple myeloma: A meta-analysis
چکیده انگلیسی

Results of available literatures, which concerned the association between TNF-α promoter −238/−308 gene polymorphisms and multiple myeloma (MM), are of great controversy. A review was performed in studies reporting on the association between them. Odds ratios (ORs) with 95% confidence interval (CI) were used to evaluate the association. The pooled ORs indicated that there was no association between TNF-α −238/−308 polymorphisms and MM susceptibility in overall population. Sub-group analysis also confirmed that no evidence supported the relevance of TNF-α promoter −238/−308 gene polymorphisms with MM. Studies with large sample size and multi-ethnics may be needed to further explore the association between them.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 37, Issue 1, January 2013, Pages 50–57
نویسندگان
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