کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2136969 | 1087827 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Diverse underlying proliferation response to growth factors in imatinib-treated Philadelphia chromosome-positive leukemias
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
Since BCR–ABL plays an essential role in the growth factor-independent proliferation of Philadelphia chromosome (Ph)+ leukemia cells, imatinib treatment of Ph+ leukemia cells inactivates signaling pathways of BCR–ABL, and subsequent addition of growth factors (GFs) could restore the signaling pathways without reactivating BCR–ABL. Here we demonstrated that non-lymphoid Ph+ leukemia cell lines responded to diverse GFs depending on their immunophenotype and gene expression of transcription factors and GF receptors, while lymphoid Ph+ leukemia cell lines restrictively responded to flit3 ligand and interleukin-7, suggesting that GF sensitivity of imatinib-treated Ph+ leukemia cells could be powerful for specifying their distinctive lineage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 37, Issue 1, January 2013, Pages 93–101
Journal: Leukemia Research - Volume 37, Issue 1, January 2013, Pages 93–101
نویسندگان
Atsushi Nemoto, Takeshi Inukai, Kanako Uno, Nobutaka Kiyokawa, Yoshitaka Miyagawa, Kazuya Takahashi, Hiroki Sato, Koshi Akahane, Kinuko Hirose, Hiroko Honna-Oshiro, Kumiko Goi, Keiko Kagami, Shinpei Nakazawa, Junichiro Fujimoto, Toshiya Inaba,