کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2137065 | 1087831 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adverse prognostic value of MYBL2 overexpression and association with microRNA-30 family in acute myeloid leukemia patients
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
The MYBL2 gene encodes a transcription factor implicated in cell proliferation and maturation whose amplification or overexpression has been associated with different human malignancies, suggesting that it could be implicated in tumorigenesis. We analyzed MYBL2 expression and its prognostic value in 291 patients with de novo acute myeloid leukemia (AML) and we also evaluated its association with microRNAs 29 and 30 families. MYBL2 expression in AML patients was increased relative to CD34+ cells. Moreover, MYBL2 overexpression was associated with lower expression of miR-30a (PÂ =Â 0.024), miR-30b (PÂ =Â 0.021) and miR-30c (PÂ =Â 0.009). Multivariate analysis showed that MYBL2 expression was an independent factor for disease-free survival (HR 3.0, 95% CI 1.5-6.0, PÂ =Â 0.002) and cumulative incidence of relapse (HR 2.6, 95% CI 1.2-5.6, PÂ =Â 0.015) in patients with an intermediate-risk karyotype. In conclusion, our data showed that MYBL2 expression analysis could be useful to define subgroups of patients with poor prognosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 37, Issue 12, December 2013, Pages 1690-1696
Journal: Leukemia Research - Volume 37, Issue 12, December 2013, Pages 1690-1696
نویسندگان
Ãscar Fuster, Marta Llop, Sandra Dolz, Paloma GarcÃa, Esperanza Such, Mariam Ibáñez, Irene Luna, Inés Gómez, MarÃa López, José Cervera, Pau Montesinos, Federico Moscardó, Lourdes Cordón, Pilar Solves, Inmaculada de Juan, Sarai Palanca,