کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2137160 | 1087834 | 2012 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
RT-PCR diagnosis of recurrent rearrangements in pediatric acute lymphoblastic leukemia in Argentina
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: RT-PCR diagnosis of recurrent rearrangements in pediatric acute lymphoblastic leukemia in Argentina RT-PCR diagnosis of recurrent rearrangements in pediatric acute lymphoblastic leukemia in Argentina](/preview/png/2137160.png)
چکیده انگلیسی
The present study was performed to establish the prevalence of the recurrent fusion transcripts in Argentinean pediatric patients with acute lymphoblastic leukemia (ALL). A total of 380 newly diagnosed children (including 50 infants and 44 T-ALL) were screened by RT-PCR; the incidence of recurrent rearrangements was: ETV6-RUNX1, 12.9%; TCF3-PBX1, 5.0%; BCR-ABL1, 1.6%; and MLL rearrangements, 10.5%. STIL-TAL1 was detected in 22.7% of T-ALL cases. In B-ALL cases, the pEFS was significantly influenced by the presence of genetic alterations. RT-PCR studies improved patients' stratification and also the overall outcome of children treated in a pediatric hospital from a developing country.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 36, Issue 6, June 2012, Pages 704-708
Journal: Leukemia Research - Volume 36, Issue 6, June 2012, Pages 704-708
نویسندگان
Cristina N. Alonso, Marta S. Gallego, Jorge G. Rossi, Adriana Medina, Patricia L. Rubio, Andrea R. Bernasconi, Pedro A. Zubizarreta, MarÃa S. Felice,