کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2137221 | 1087837 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia](/preview/png/2137221.png)
چکیده انگلیسی
In vivo effects of the DNA hypomethylating agent 5-aza-2′-deoxycytidine (DAC) upon the epigenome of acute myeloid leukemia (AML) patients are scarcely studied in primary blasts. Here, we sequentially assessed DNA methylation and transcriptome changes in myeloblasts of DAC-treated AML patients. DNA methylation changes were detected in all patients already after the first series of infusion (median: 6 days). LINE1 analysis indicated global DNA methylation decrease in 7/8 patients. Gene-specific hypomethylating effects were not directly linked to mRNA expression changes. In conclusion, complex DAC-induced DNA methylation changes occur very early and imply mechanisms distinct from non-hypomethylating cytosine analogs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 37, Issue 2, February 2013, Pages 190–196
Journal: Leukemia Research - Volume 37, Issue 2, February 2013, Pages 190–196
نویسندگان
Rainer Claus, Dietmar Pfeifer, Maika Almstedt, Manuela Zucknick, Björn Hackanson, Christoph Plass, Michael Lübbert,