کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2137567 1087851 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Methods for measuring proteasome activity: Current limitations and future developments
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Methods for measuring proteasome activity: Current limitations and future developments
چکیده انگلیسی

The proteasome has been validated as a therapeutic target, with proteasome inhibitors showing particular efficacy in the treatment of Multiple Myeloma. A wide range of methods have been developed to profile proteasome activity. These include the current method of choice fluorogenic peptide substrates, as well as bioluminescent imaging, immunological methods, and more recently, site-specific fluorescent probes. The aim of this review is to evaluate the currently available methods for profiling proteasome activity and their suitability for use in translational studies. Ongoing development of techniques for profiling proteasome activity will facilitate future research into proteasome-related pathologies, thus accelerating the development of more specific drug regimes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 34, Issue 11, November 2010, Pages 1403–1409
نویسندگان
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