کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2138304 | 1087873 | 2007 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gene stage-specific expression in the microenvironment of pediatric myelodysplastic syndromes
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Gene stage-specific expression in the microenvironment of pediatric myelodysplastic syndromes Gene stage-specific expression in the microenvironment of pediatric myelodysplastic syndromes](/preview/png/2138304.png)
چکیده انگلیسی
Using cDNA microarray assays we have observed a clear difference in the gene expression pattern between bone marrow stromal cells obtained from healthy children (CT) and from pediatric patients with either myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) associated with MDS (MDS–AML). The global gene function profiling analysis indicated that in the pediatric MDS microenvironment the disease stages may be characterized mainly by underexpression of genes associated with biological processes such as transport. Furthermore, a subset of downregulated genes related to endocytosis and protein secretion was able to discriminate MDS from MDS–AML.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 31, Issue 5, May 2007, Pages 579–589
Journal: Leukemia Research - Volume 31, Issue 5, May 2007, Pages 579–589
نویسندگان
Rosimeire A. Roela, Dirce M. Carraro, Helena P. Brentani, Jane H.L. Kaiano, Daniel F. Simão, Roberto Guarnieiro, Luiz Fernando Lopes, Radovan Borojevic, M. Mitzi Brentani,