کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2138381 1087875 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hybrid liposomes inhibit the growth of primary effusion lymphoma in vitro and in vivo
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Hybrid liposomes inhibit the growth of primary effusion lymphoma in vitro and in vivo
چکیده انگلیسی

Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) infection. It occurs predominantly in human immunodeficiency virus (HIV)-positive patients, is generally resistant to chemotherapy, and has a poor prognosis. Hybrid liposomes (HL), composed of dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene dodecyl ether, inhibited PEL cell proliferation and induced apoptosis in vitro. Intraperitoneal inoculation of the BCBL-1 PEL cell line into NOD/Scid/Jak3 deficient mice induced massive ascites, which were inhibited by HL21 without significant systemic toxicity in the mice. These results suggest that HL21 is an effective and attractive reagent for PEL treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 34, Issue 7, July 2010, Pages 906–911
نویسندگان
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