کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2138383 1087875 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents
چکیده انگلیسی

We used a novel high-throughput drug screening assay, based on Luminex technology, to identify anti-myeloma agents capable of inhibiting cytokines and growth factors essential for multiple myeloma (MM) from a chemical library of 1120 compounds provided by MMRF. Tetracycline derivatives inhibited MM cell proliferation and osteoclast activating factors without obvious effect on cell viability. Steroid compounds specifically decreased angiogenesis-related factors, but stimulated osteoclast activating factors. Antihelmintic drugs potently inhibited cytokines and were cytotoxic. The screen identified potential candidates with potent anti-MM properties that need further investigation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 34, Issue 7, July 2010, Pages 917–924
نویسندگان
, , , , , ,