کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2138430 1087876 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High FOXO3a expression is associated with a poorer prognosis in AML with normal cytogenetics
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
High FOXO3a expression is associated with a poorer prognosis in AML with normal cytogenetics
چکیده انگلیسی

The PI3/AKT pathway is up-regulated in acute myeloid leukemia (AML), but its prognostic relevance in cytogenetically normal AML (CN-AML) is unclear. We evaluated RNA levels of AKT and two downstream substrates (FOXO3a-p27) in 110 de novo CN-AML, included in the Spanish PETHEMA therapeutic protocols. Patients with high FOXO3a gene expression displayed shorter OS (p = 0.015) and RFS (p = 0.048) than low FOXO3a expressers. Features selected in the multivariate analysis as having an independent prognostic value for a shorter survival were WBC > 50 × 109/L, age >65 years and high FOXO3a expression. We concluded that FOXO3a assessment could contribute to improve the molecular-based risk stratification in CN-AML.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 33, Issue 12, December 2009, Pages 1706–1709
نویسندگان
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