کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2138766 | 1087885 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Absence of renal lesions in C57BL/KaLwRij mice with advanced myeloma due to 5T2MM cells
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Absence of renal lesions in C57BL/KaLwRij mice with advanced myeloma due to 5T2MM cells Absence of renal lesions in C57BL/KaLwRij mice with advanced myeloma due to 5T2MM cells](/preview/png/2138766.png)
چکیده انگلیسی
Renal failure is one of the main complications in multiple myeloma (MM) and histopathological lesions are due to light chains accumulation in the kidney. The 5T2MM mouse model closely mimics osteolytic lesions observed in clinics. We studied the occurrence of pathological changes in the kidney of mice inoculated with 5T2MM myeloma cells. No renal lesions due to light chain deposition were observed after histological, immunological staining and dosage of creatinine in serum and urine. PTH levels decreased in 5T2MM mice, confirming the absence of secondary hyperparathyroidism. Osteolytic lesions appear to be the unique consequence of 5T2MM cells inoculation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 30, Issue 11, November 2006, Pages 1371–1375
Journal: Leukemia Research - Volume 30, Issue 11, November 2006, Pages 1371–1375
نویسندگان
Hélène Libouban, Céline Onno, Florence Pascaretti-Grizon, Yves Gallois, Marie-Françoise Moreau, Michel F. Baslé, Daniel Chappard,