کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2138844 1087887 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Semenogelin I expression in myeloma cells can be upregulated pharmacologically
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Semenogelin I expression in myeloma cells can be upregulated pharmacologically
چکیده انگلیسی
Semenogelin (SEMG) I is a Cancer-Testis (CT) antigen that we have found to be expressed in myeloma cells. In this study, we set out to determine whether the expression of SEMG I could be upregulated pharmacologically. We found that SEMG I expression in myeloma cells can be upregulated by 5-azacytidine, IL-4 and IL-6. The mechanisms of SEMG I gene upregulation by 5-azacytidine is unclear since there was no correlation between the methylation of the single CpG dinucleotide at position −11 and SEMG I expression. Both IL-4 and IL-6 appeared to enhance SEMG I expression through increasing its promoter function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 32, Issue 12, December 2008, Pages 1889-1894
نویسندگان
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