کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2139278 | 1087899 | 2008 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Apoptosis induction by Maackia amurensis agglutinin in childhood acute lymphoblastic leukemic cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Apoptosis induction by Maackia amurensis agglutinin in childhood acute lymphoblastic leukemic cells Apoptosis induction by Maackia amurensis agglutinin in childhood acute lymphoblastic leukemic cells](/preview/png/2139278.png)
چکیده انگلیسی
Malignant transformation is known to be associated with changes in cell surface carbohydrate-architecture, which can be detected by lectins. In the present study, Maackia amurensis agglutinin (MAA), specific for NeuNAcα(2 â 3)Gal/GalNAc showed strong binding with lymphoblasts of children having acute lymphoblastic leukemia (ALL) as compared to cells from children with non-hematological disorders (“Controls”). MAA recognized a 66 kDa sialoglycoprotein present in membrane fraction of ALL cells. Moreover, MAA induced apoptosis in ALL cells was found to be reduced significantly in presence of GM2/IgGMAA. Thus, MAA has a potential to be used as diagnostic and therapeutic agent in case of childhood-ALL.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 32, Issue 4, April 2008, Pages 559-567
Journal: Leukemia Research - Volume 32, Issue 4, April 2008, Pages 559-567
نویسندگان
Sarika Kapoor, Ram Marwaha, Siddhartha Majumdar, Sujata Ghosh,