کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2139412 | 1087903 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
HA14-1, a small molecule inhibitor of Bcl-2, bypasses chemoresistance in leukaemia cells
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: HA14-1, a small molecule inhibitor of Bcl-2, bypasses chemoresistance in leukaemia cells HA14-1, a small molecule inhibitor of Bcl-2, bypasses chemoresistance in leukaemia cells](/preview/png/2139412.png)
چکیده انگلیسی
We analyzed the biological activity of HA14-1, a small organic compound inhibitor of Bcl-2, against established leukaemia cell lines and blasts from acute myeloid leukaemia (AML) patients. HA14-1 had a potent killing activity against the leukaemia cell line that expressed endogenous or ectopic Bcl-2. This activity was mostly caspase-independent and was not altered by the expression of a multidrug-resistant phenotype. Moreover, HA14-1 efficiently induced cell death in a broad spectrum of AML blasts but not in normal peripheral blood lymphocytes. Thus, single-agent regimens using Bcl-2 inhibitors such as HA14-1 may be advantageous in overcoming some forms of chemoresistance in AML.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 31, Issue 6, June 2007, Pages 859–863
Journal: Leukemia Research - Volume 31, Issue 6, June 2007, Pages 859–863
نویسندگان
Lisa Oliver, Béatrice Mahé, René Gréé, François M. Vallette, Philippe Juin,