Keywords: مهار کننده های مولکولی کوچک; PRP; Nutraceuticals; LLLT; Small molecule inhibitors;
مقالات ISI مهار کننده های مولکولی کوچک (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: مهار کننده های مولکولی کوچک; Immunotherapies; monoclonal antibodies; small molecule inhibitors; targeted therapies;
Keywords: مهار کننده های مولکولی کوچک; Biologics; small molecule inhibitors; topical therapy; cytokines; mAbs; precision medicine; AD; Atopic dermatitis; AhR; Aryl hydrocarbon receptor; CRTH2; Chemoattractant receptor homologous molecules expressed on TH2 lymphocytes; EASI; Eczema Area and Sev
Keywords: مهار کننده های مولکولی کوچک; insulin degrading enzyme; type 2 diabetes mellitus; Alzheimer's disease; small molecule inhibitors
Keywords: مهار کننده های مولکولی کوچک; Urothelial carcinoma; Targeted therapy; Small molecule inhibitors; Next-generation sequencing; Angiogenesis; MAPK pathway; PI3K/Akt/mTOR pathway;
Keywords: مهار کننده های مولکولی کوچک; Chronic lymphocytic leukemia; Duvelisib; Ibrutinib; Idelalisib; Monoclonal antibodies; Obinutuzumab; Small molecule inhibitors; Venetoclax;
Keywords: مهار کننده های مولکولی کوچک; Cancer therapeutics; Small molecule inhibitors; Proteasome; Deubiquitinase; DUB; α,βâUnsaturated ketones; Apoptosis;
Keywords: مهار کننده های مولکولی کوچک; Inhibitor of Apoptosis Proteins (IAPs); Cancer; SMAC; MD simulations; Small molecule inhibitors;
Keywords: مهار کننده های مولکولی کوچک; Bromodomain; Gene transcription; Small molecule inhibitors;
Keywords: مهار کننده های مولکولی کوچک; Immune thrombocytopenia; Phagocytosis; IVIG; Small molecule inhibitors; Macrophages;
Keywords: مهار کننده های مولکولی کوچک; Adenovirus; Factor X; Small molecule inhibitors;
Keywords: مهار کننده های مولکولی کوچک; ACTDs; autoimmune connective tissue diseases; SLE; systemic lupus erythematosus; RA; rheumatoid arthritis; SSc; systemic sclerosis; SS; Sjögren's syndrome; MCTD; mixed connective tissue disease; TLRs; IL-1R-like receptors; DAMPs; danger-associated molecu
Discovery of small molecule inhibitors of adenovirus by disrupting E3-19K/HLA-A2 interactions
Keywords: مهار کننده های مولکولی کوچک; Adenovirus; E3-19K; HLA-A2; Protein-protein interactions; Small molecule inhibitors; Molecular dynamic simulations; Molecular mechanics/generalized-born surface area (MM/GBSA); Computational solvent mapping; Virtual screening; Surface plasmon resonance;
Synthesis and bioactivity of thiazolidin-2-cyanamide derivatives against type III secretion system of Xanthomonas oryzae on rice
Keywords: مهار کننده های مولکولی کوچک; Xanthomonas oryzae pv. oryzae (Xoo); Type III secretion system (T3SS); Small molecule inhibitors; Virulence factors; Thiazolidin-2-cyanamide; Synthesis;
CAR-T cells and combination therapies: What's next in the immunotherapy revolution?
Keywords: مهار کننده های مولکولی کوچک; CAR; chimeric antigen receptor; iRs; inhibitory receptors; mAbs; monoclonal antibodies; SMIs; Small molecule inhibitors; KIs; kinase inhibitors; CAR-T cells; Solid tumors; Targeted-therapies; Combination therapies; Synthetic biology; Systems biology;
Bcl-2 inhibitors as anti-cancer therapeutics: The impact of and on calcium signaling
Keywords: مهار کننده های مولکولی کوچک; Ca2+ signaling; Apoptosis; Anti-apoptotic proteins; Small molecule inhibitors; BH3 mimetics; BH4-domain-targeting compounds;
Inhibiting glycogen synthase kinase-3 and transforming growth factor-β signaling to promote epithelial transition of human adipose mesenchymal stem cells
Keywords: مهار کننده های مولکولی کوچک; Mesenchymal-epithelial transition; Adipose-derived stem cells; Small molecule inhibitors; Glycogen synthase kinase-3; Transforming growth factor-β;
Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types
Keywords: مهار کننده های مولکولی کوچک; ITPKA; Lung cancer; Small molecule inhibitors; Inositol; Actin;
Targeting the PD-1/PD-L1 axis in non-small cell lung cancer
Keywords: مهار کننده های مولکولی کوچک; Non-small cell lung cancer; PD-1; PD-L1; Immune checkpoint inhibitors; Chemotherapy; Radiotherapy; Small molecule inhibitors; CTLA-4 antagonists;
Mini-reviewPotential therapeutic targets of epithelial-mesenchymal transition in melanoma
Keywords: مهار کننده های مولکولی کوچک; Melanoma; Epithelial-mesenchymal transition; Invasion; Signaling pathways; Phytochemicals; Small molecule inhibitors;
Cancer combination therapy of the sesquiterpenoid artesunate and the selective EGFR-tyrosine kinase inhibitor erlotinib
Keywords: مهار کننده های مولکولی کوچک; Cancer; Natural products; Small molecule inhibitors; Synergy;
A comprehensive review on Aurora kinase: Small molecule inhibitors and clinical trial studies
Keywords: مهار کننده های مولکولی کوچک; Aurora kinase; Aurora-A; Aurora-B; Aurora-C; INCENP; Small molecule inhibitors;
The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear
Keywords: مهار کننده های مولکولی کوچک; DUB; Deubiquitinase; ERAD; endoplasmic-reticulum associated degradation; ESI; electrospray ionization; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; ITC; isothermal titration calorimetry; ML; maximum-likelihood; RING; really-interesting new g
A small molecule neutrophil elastase inhibitor, KRP-109, inhibits cystic fibrosis mucin degradation
Keywords: مهار کننده های مولکولی کوچک; Small molecule inhibitors; Protease and anti-protease balance; Cystic fibrosis; Mucin;
Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness
Keywords: مهار کننده های مولکولی کوچک; GroEL; GroES; HSP60; HSP10; Molecular chaperone; Chaperonin; Proteostasis; Small molecule inhibitors; Antibiotics; Parasites; Trypanosoma brucei; African sleeping sickness;
GroEL/ES inhibitors as potential antibiotics
Keywords: مهار کننده های مولکولی کوچک; GroEL; GroES; HSP60; HSP10; Molecular chaperone; Chaperonin; Proteostasis; Small molecule inhibitors; ESKAPE pathogens; Antibiotics
Progress and prospects on DENV protease inhibitors
Keywords: مهار کننده های مولکولی کوچک; Dengue; NS2B-NS3 protease; Proteolytic mechanism; Peptide inhibitors; Peptide conjugates; Small molecule inhibitors; Natural products; HTS; HTVS;
Identification of inhibitors of bacterial RNA polymerase
Keywords: مهار کننده های مولکولی کوچک; RNA polymerase; Transcription initiation; Small molecule inhibitors; Protein-protein interaction;
Identification of small molecule inhibitors of the STAT3 signaling pathway: Insights into their structural features and mode of action
Keywords: مهار کننده های مولکولی کوچک; STAT3; Small molecule inhibitors; Apoptosis; Antitumor; Breast cancer;
In silico investigation of FOXM1 binding and novel inhibitors in epithelial ovarian cancer
Keywords: مهار کننده های مولکولی کوچک; In silico; FOXM1; Ovarian cancer; Small molecule inhibitors; Thiazole antibiotics;
The new InsP3Kinase inhibitor BIP-4 is competitive to InsP3 and blocks proliferation and adhesion of lung cancer cells
Keywords: مهار کننده های مولکولی کوچک; Small molecule inhibitors; Cell proliferation; Cellular adhesion; Migration; InsP3Kinase; Cellular uptake;
Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1
Keywords: مهار کننده های مولکولی کوچک; Aldehyde dehydrogenase; Retinaldehyde dehydrogenase; High-throughput screen; Small molecule inhibitors; Enzyme inhibition
Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer
Keywords: مهار کننده های مولکولی کوچک; STAT3; NSCLC; Small molecule inhibitors;
Identification of 2-aminopyrimidine derivatives as inhibitors of the canonical Wnt signaling pathway
Keywords: مهار کننده های مولکولی کوچک; APC; adenomatous polyposis coli; CK1; casein kinase-1; CYP3A4; Cytochrome P450 3A4; FPSA; fractional polar surface area; Fz; frizzled; GSK3; glycogen synthase kinase 3; LEF; lymphoid enhancer-binding factor; LRP; lipoprotein receptor-related protein; MW;
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics
Keywords: مهار کننده های مولکولی کوچک; Sirtuins; Small molecule inhibitors; Anticancer drugs; Chemotherapy; Quinazolinedione; Molecular design; NAD+-dependent deacetylases
KRAS and HRAS mutations confer resistance to MET targeting in preclinical models of MET-expressing tumor cells
Keywords: مهار کننده های مولکولی کوچک; MET; RAS; Mutations; Small molecule inhibitors; Resistance;
Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3)
Keywords: مهار کننده های مولکولی کوچک; STAT3; Transcription factors; Small molecule inhibitors; Anticancer drugs; Cancer therapy; Mechanism of action; Computational modeling; Molecular dynamic simulation; Site-directed mutagenesis;
Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy
Keywords: مهار کننده های مولکولی کوچک; BRCA1; Base excision repair; ATM; DNA-PK; Small molecule inhibitors; Synthetic lethality; Cisplatin; Chemopotentiation;
Associate editor: B. TeicherDeubiquitinase inhibition as a cancer therapeutic strategy
Keywords: مهار کننده های مولکولی کوچک; Cancer therapeutics; Small molecule inhibitors; Proteasome; Deubiquitinase; α,β-unsaturated ketones; Apoptosis; 19S RP; 19S regulatory particle; 20S CP; 20S core particle; ASK1; apoptosis signaling kinase 1; BRCA1; breast cancer type 1 susceptibility pr
A biochemical screen for GroEL/GroES inhibitors
Keywords: مهار کننده های مولکولی کوچک; GroEL; GroES; Chaperonin; High-throughput screening; Small molecule inhibitors;
Pseudomonas aeruginosa biofilm: Potential therapeutic targets
Keywords: مهار کننده های مولکولی کوچک; Biofilm; Exopolysaccharides (EPS); Pseudomonas aeruginosa; Nanoparticles; Small molecule inhibitors; Therapeutics
Mechanisms of RET signaling in cancer: Current and future implications for targeted therapy
Keywords: مهار کننده های مولکولی کوچک; RTK; Signaling; Cancer; Kinase; Small molecule inhibitors;
Current challenges and clinical investigations of epidermal growth factor receptor (EGFR)- and ErbB family-targeted agents in the treatment of head and neck squamous cell carcinoma (HNSCC)
Keywords: مهار کننده های مولکولی کوچک; Epidermal growth factor receptor; EGFR; ErbB1; Human epidermal growth factor receptor 1; Monoclonal antibodies; Small molecule inhibitors; Head and neck squamous cell carcinoma
NFAT as cancer target: Mission possible?
Keywords: مهار کننده های مولکولی کوچک; ADP; adenosine di-phosphate; AICD; activation-induced cell death; AKAP79; A-kinase anchor protein 79; Ang-2; angiopoietin-2; AP1; activator protein 1; ARRE-2; antigen receptor response element-2; BMP4; bone morphogenetic protein 4; CABIN1; calcineurin-bin
Evaluation of molecular model-based discovery of ecto-5â²-nucleotidase inhibitors on the basis of X-ray structures
Keywords: مهار کننده های مولکولی کوچک; Ecto-5â²-nucleotidase; Small molecule inhibitors; Docking; Virtual screening; Comparative protein models; X-ray structures;
Targeting the Heat Shock Response in Cancer
Keywords: مهار کننده های مولکولی کوچک; Heat shock response; HSF-1; Curaxins; Small molecule inhibitors;
Design and synthesis of boronic acid inhibitors of endothelial lipase
Keywords: مهار کننده های مولکولی کوچک; Endothelial lipase; Boronic acids; Small molecule inhibitors; HDL-cholesterol; Lipoprotein lipase
Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction
Keywords: مهار کننده های مولکولی کوچک; Mcl-1; Bcl-2; Protein-protein interactions; Small molecule inhibitors; Anticancer agents;
Inhibition in vivo of the activity of botulinum neurotoxin A by small molecules selected by virtual screening
Keywords: مهار کننده های مولکولی کوچک; Botulinum neurotoxin A; Small molecule inhibitors; Virtual screening; In vivo activity; Mouse protection assay; BoNT; botulinum neurotoxin; Glide; Grid-based ligand docking energetics; MPA; mouse protection assay; SP; Standard precision; VS; virtual scre
Innovative therapy for Classic Galactosemia - Tale of two HTS
Keywords: مهار کننده های مولکولی کوچک; Classic Galactosemia; Small molecule inhibitors; High-throughput screening; Drug discovery; Galactokinase; Anti-cancer therapy;