کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2139473 | 1087906 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Idiopathic cytopenia of undetermined significance (ICUS) versus low risk MDS: The diagnostic interface
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
It may sometimes be difficult to diagnose low risk MDS in patients with mild cytopenia. We report on 10 patients with mild to marked, unexplained cytopenia without definitive signs of a myeloid neoplasm. In two patients, a karyotype-abormality (trisomy 14; monosomy 7) was detected in a small subset of bone marrow cells. Progression to overt MDS was seen in two patients including the one with monosomy 7. In the remaining cases, no MDS developed in a follow-up of at least 6 months. The phrase “idiopathic cytopenia of undetermined significance (ICUS)”, as also suggested by Mufti and co-workers, is proposed and long term follow-up is recommended to assess the evolution.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 31, Issue 11, November 2007, Pages 1461–1468
Journal: Leukemia Research - Volume 31, Issue 11, November 2007, Pages 1461–1468
نویسندگان
Friedrich Wimazal, Christa Fonatsch, Renate Thalhammer, Ilse Schwarzinger, Leonhard Müllauer, Wolfgang R. Sperr, John M. Bennett, Peter Valent,