کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2139475 | 1087906 | 2007 | 7 صفحه PDF | دانلود رایگان |
Chronic exposure to benzene can result in transient hematotoxicity (benzene poisoning, BP) or persistent bone marrow pathology including dysplasia and/or acute myeloid leukemia. We recently described a persistent bone marrow dysplasia with unique dysplastic and inflammatory features developing in individuals previously exposed to benzene (BID) [Irons RD, Lv L, Gross SA, Ye X, Bao L, Wang XQ, et al. Chronic exposure to benzene results in a unique form of dysplasia. Leuk Res 2005;29:1371–80]. In this study we investigated the association of single nucleotide polymorphisms (SNP) (−863 (C → A), −857 (C → T), −308 (G →A ), −238 (G → A)) in the promoter region of the cytokine, tumor necrosis factor-alpha (TNF-α) on the development of BP, persistent BID and de novo myelodysplastic syndrome (MDS) in 394 individuals. Only the −238 (G → A) polymorphism was significantly associated with the development of BID (odds ratio (OR) = 7.4; 95% C.I. 1.23–44.7) and was specific for BID and not de novo MDS or BP. These findings are consistent with a role for inflammation in the development of BID and suggest that cell-specific alterations in TNF-α expression may promote clonal selection in the evolution of neoplastic hematopoietic disease.
Journal: Leukemia Research - Volume 31, Issue 11, November 2007, Pages 1479–1485