کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2140288 | 1088228 | 2014 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Hemophagocytic lymphohistiocytosis secondary to T-cell/histiocyte-rich large B-cell lymphoma Hemophagocytic lymphohistiocytosis secondary to T-cell/histiocyte-rich large B-cell lymphoma](/preview/png/2140288.png)
• We present an uncommon case of HLH associated with TCHRBCL with cytotoxic T-cells.
• The case highlights the interplay between immune hyperactivation and tumor immune evasion.
• Treatment considerations for this difficult case based on updated guidelines are reviewed.
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening clinical syndrome characterized by dysregulation of the immune system. Impaired function of cytotoxic T cells and natural killer cells is often seen, and T-cell malignancies represent most cases of lymphoma-associated HLH. HLH associated with B-cell lymphoma is rare. We describe a case of a 30-year-old man who presented with fever, splenomegaly, and hyperferritinemia. Bone marrow biopsy revealed T-cell/histiocyte-rich large B-cell lymphoma, a rare, aggressive B-cell malignancy. This case highlights the interplay between a pro-inflammatory cytokine microenvironment and tumor-mediated immune suppression, and addresses the importance of accurately diagnosing these entities for appropriate clinical management.
Journal: Leukemia Research Reports - Volume 3, Issue 2, 2014, Pages 42–45