کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2142567 1088321 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic variants in GTF2H1 and risk of lung cancer: A case–control analysis in a Chinese population
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Genetic variants in GTF2H1 and risk of lung cancer: A case–control analysis in a Chinese population
چکیده انگلیسی

SummaryGTF2H1, the p62 subunit of the multiprotein complex transcription factor IIH (TFIIH), participates in both the nucleotide excision repair process and transcription control by specifically interacting with a variety of factors important in carcinogenesis. To elucidate the role of genetic variation in GTF2H1 in the etiology of lung cancer, we conducted a case–control study of 500 incident lung cancer cases and 517 controls in a Chinese population by genotyping six common single nucleotide polymorphisms (SNPs) in GTF2H1. An increased risk was associated with the variant genotypes of rs3802967 [adjusted odds ratio (OR) = 1.38, 95% confidence interval (CI) = 1.04–1.82], rs4150606 (adjusted OR = 1.44, 95% CI = 1.08–1.92), and rs4150678 (adjusted OR = 1.37, 95% CI = 1.04–1.81) in a dominant genetic model. The risk for rs3802967 C/T + T/T genotypes was more pronounced among males subjects (P = 0.002). In contrast, a decreased risk was associated with the rs4150667 T/T genotype (adjusted OR = 0.59, 95% CI = 0.38–0.93) in a recessive model. Haplotype analysis showed that the haplotype “222212” (1 for common alleles and 2 for minor alleles) was associated with increased risk of lung cancer (P = 0.03). Further evaluation using luciferase reporter constructs showed that the T allele of rs3802967 had higher luciferase expression, suggesting that the -79C→T change may affect transcriptional activation of GTF2H1. Taken together, these results suggest that GTF2H1 polymorphisms/haplotypes may contribute to genetic susceptibility to lung cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 63, Issue 2, February 2009, Pages 180–186
نویسندگان
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