کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2143044 1088332 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-lung cancer effects of novel ginsenoside 25-OCH3-PPD
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Anti-lung cancer effects of novel ginsenoside 25-OCH3-PPD
چکیده انگلیسی

20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol (25-OCH3-PPD), a newly identified natural product from Panax notoginseng, exhibits activity against a variety of cancer cells. Herein, we report the effects of this compound on human A549, H358, and H838 lung cancer cells, and compare these effects with a control lung epithelial cell line, BEAS-2B. 25-OCH3-PPD decreased survival, inhibited proliferation, and induced apoptosis and G1 cell cycle arrest in the lung cancer cell lines. The P. notoginseng compound also decreased the levels of proteins associated with cell proliferation and cell survival. Moreover, 25-OCH3-PPD inhibited the growth of A549 lung cancer xenograft tumors. 25-OCH3-PPD demonstrated low toxicity to non-cancer cells, and no observable toxicity was seen when the compound was administered to animals. In conclusion, our preclinical data indicate that 25-OCH3-PPD is a potential therapeutic agent in vitro and in vivo, and further preclinical and clinical development of this agent for lung cancer is warranted.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 65, Issue 3, September 2009, Pages 306–311
نویسندگان
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