کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2143774 | 1088358 | 2007 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A multi-center phase II study of weekly topotecan as second-line therapy for small cell lung cancer A multi-center phase II study of weekly topotecan as second-line therapy for small cell lung cancer](/preview/png/2143774.png)
SummaryPurposeTo determine the response rate, toxicity, failure free and overall survival of weekly topotecan in patients with relapsed small cell lung cancer who received one prior platinum based chemotherapy.Patients and methodsTwenty two patients with relapsed disease after response to one prior chemotherapy with or without radiotherapy and patients with relapse more than 90 days after their last therapy received topotecan 4 mg/m2 intravenous over 30 min on days 1,8,15; every 4 weeks (3 weeks on and 1 weeks off). Chemotherapy was given until disease progression or unacceptable toxicity.ResultsOf 22 patients, none of the patients responded to weekly topotecan therapy. Four patients had stable disease. After a median follow up of 1 year, median time to progression was 6 weeks and median survival was 5 months. The common toxicities associated with this regimen were anemia, thrombocytopenia, fatigue, GI side effects and alopecia.ConclusionWeekly topotecan was well tolerated but ineffective in this trial. Although commonly used, weekly regimen of topotecan should be used with caution in relapsed SCLC.
Journal: Lung Cancer - Volume 57, Issue 1, July 2007, Pages 84–88