کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2143902 1088364 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-domain (NOK) in lung cancers
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-domain (NOK) in lung cancers
چکیده انگلیسی

SummaryThere have been no target molecules that have enabled us to diagnose lung cancer with high sensitivity and specificity even in its early clinical stages. A molecule termed novel oncogene with kinase-domain (NOK) was recently reported as a receptor protein tyrosine kinase that is expressed in some cancer cell lines and causes the transformation and progressive proliferation of normal cells. Therefore, NOK could be a possible candidate for a diagnostic marker for human cancers. We examined here, the degree of NOK mRNA expression in lung cancer tissues and compared it to that in non-cancerous tissues. More than 60% of non-cancerous samples (8/13) showed undetectable levels of mRNA. In contrast, NOK mRNA was detected in 97.6% (40/41) of lung cancer tissues, resulting in a sensitivity of 80.5% and a specificity of 92.3% that was estimated using the cutoff obtained from receiver operating characteristic curve analysis. Further, NOK mRNA expression was found to be elevated in 92.3% (12/13) of cancerous tissues when paired cancerous and non-cancerous tissues from identical patients were compared. There were no obvious correlations between clinicopathological factors and NOK mRNA expression; however, NOK mRNA was highly expressed even at the early clinical stages of the cancer. These results suggest that NOK mRNA might be a new tool to support the diagnosis of lung cancers, irrespective of the clinical stages.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 56, Issue 3, June 2007, Pages 337–340
نویسندگان
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