کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2144580 1088387 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Peptide ligands targeting integrin α3β1 in non-small cell lung cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Peptide ligands targeting integrin α3β1 in non-small cell lung cancer
چکیده انگلیسی

SummaryLung cancer is one of the most common cancers and is the leading cause of cancer death. We wish to identify peptide ligands for unique cell surface receptors of non-small lung cancer with the hope of developing these ligands as diagnostic and therapeutic agents. Using the method of ‘one-bead one-peptide’ combinatorial chemistry, a library of random cyclic octapeptides was synthesized on polystyrene beads. This library was used to screen for peptides that promoted attachment of lung adenocarcinoma cells employing a ‘cell-growth-on-bead’ assay. Consensus peptide sequences of cNGXGXXc were identified. These peptides promoted cell adhesion by targeting integrin α3β1 over-expressed in non-small lung cancer cells. These peptide beads can be applied to capture cancer cells in malignant pleural fluid for purpose of diagnosis of lung cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 52, Issue 3, June 2006, Pages 291–297
نویسندگان
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