کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2144631 | 1088395 | 2006 | 7 صفحه PDF | دانلود رایگان |
SummaryMalignant pleural mesothelioma (MPM) is a highly chemoresistant cancer with a poor prognosis. Hypoxia is a specific property of solid tumours, contributes to low apoptotic potential, and can be selectively targeted by bioreductive drugs. Hypoxia-inducible factor 1α (HIF-1α) is a subunit of a heterodimeric transcription complex that regulates several genes associated with tumour progression and anti-apoptosis. In this study, we measured for the first time the expression of HIF-1α in MPM. Our results show that HIF-1α is commonly expressed in MPM but not in normal mesothelium, consistent with the presence of hypoxia. HIF-1α does not appear to predict survival; however, this study suggests that bioreductive drugs should be investigated in clinical trials of MPM.
Journal: Lung Cancer - Volume 51, Issue 1, January 2006, Pages 53–59