کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2144720 1548012 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
EMMPRIN, an upstream regulator of MMPs, in CNS biology
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
EMMPRIN, an upstream regulator of MMPs, in CNS biology
چکیده انگلیسی


• EMMPRIN is upregulated in diseases of the nervous system.
• The elevated EMMPRIN helps modulate MMP expression within the nervous system.
• EMMPRIN likely has multiple roles with the brain, including in protective functions.

Matrix metalloproteinases (MMPs) are engaged in pathologies associated with infections, tumors, autoimmune disorders and neurological dysfunctions. With the identification of an upstream regulator of MMPs, EMMPRIN (Extracellular matrix metalloproteinase inducer, CD147), it is relevant to address if EMMPRIN plays a role in the pathology of central nervous system (CNS) diseases. This would enable the possibility of a more upstream and effective therapeutic target. Indeed, conditions including gliomas, Alzheimer's disease (AD), multiple sclerosis (MS), and other insults such as hypoxia/ischemia show elevated levels of EMMPRIN which correlate with MMP production. In contrast, given EMMPRIN's role in CNS homeostasis with respect to regulation of monocarboxylate transporters (MCTs) and interactions with adhesion molecules including integrins, we need to consider that EMMPRIN may also serve important regulatory or protective functions. This review summarizes the current understanding of EMMPRIN's involvement in CNS homeostasis, its possible roles in escalating or reducing neural injury, and the mechanisms of EMMPRIN including and apart from MMP induction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Matrix Biology - Volumes 44–46, May–July 2015, Pages 138–146
نویسندگان
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