کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2144731 1548012 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New strategies for targeting matrix metalloproteinases
ترجمه فارسی عنوان
استراتژی های جدید برای هدف گیری ماتریکس متالوپروتئیناز
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


• Matrix metalloproteinase (MMP) inhibitor design has considered secondary binding sites (exosites) to improve specificity.
• Small molecules and peptides have been developed that bind exosites in MMP-2, MMP-9, MMP-13, and MT1-MMP.
• Antibody-based approaches have resulted in selective inhibitors for MMP-9 and MT1-MMP.
• Biomolecules designed for specific exosite targeting have provided selective MMP probes.

The development of matrix metalloproteinase (MMP) inhibitors has often been frustrated by a lack of specificity and subsequent off-target effects. More recently, inhibitor design has considered secondary binding sites (exosites) to improve specificity. Small molecules and peptides have been developed that bind exosites in the catalytic (CAT) domain of MMP-13, the CAT or hemopexin-like (HPX) domain of MT1-MMP, and the collagen binding domain (CBD) of MMP-2 and MMP-9. Antibody-based approaches have resulted in selective inhibitors for MMP-9 and MT1-MMP that target CAT domain exosites. Triple-helical “mini-proteins” have taken advantage of collagen binding exosites, producing a family of novel probes. A variety of non-traditional approaches that incorporate exosite binding into the design process has yielded inhibitors with desirable selectivities within the MMP family.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Matrix Biology - Volumes 44–46, May–July 2015, Pages 239–246
نویسندگان
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