کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2145303 1088670 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intracellular localization of the matrix enzyme lysyl oxidase in polarized epithelial cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Intracellular localization of the matrix enzyme lysyl oxidase in polarized epithelial cells
چکیده انگلیسی
Considerable evidence supports novel functions for lysyl oxidase (LOX) beyond its traditional role in initiating cross-linkages in collagen and elastin within the extracellular matrix. These novel roles are particularly relevant during the transition of malignant epithelial cells towards a migratory and invasive phenotype. However, knowledge on cellular and matrix functions of LOX has been generated almost exclusively in mesenchymal cell types. But it is becoming increasingly evident that these cell types are not adequate to address these novel and highly significant roles for LOX in epithelial tissues. In this initial report, we demonstrate that active LOX is expressed by polarized MDCK II kidney and MCF-10A breast epithelial cells. Furthermore, we show evidence for the presence of mature LOX in the cytoplasm and establish these cell lines as models for epithelial LOX studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Matrix Biology - Volume 26, Issue 2, March 2007, Pages 136-139
نویسندگان
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