کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2145493 | 1088680 | 2006 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage](/preview/png/2145493.png)
چکیده انگلیسی
These observations reveal that peptides of type II collagen, to which there is increased exposure in osteoarthritic cartilage, can when present in sufficient concentration induce cleavage of type II collagen (CB12-II) and aggrecan (CB12-IV) accompanied by increased expression of collagenases. Such increased concentrations of denatured collagen are present in adult and osteoarthritic cartilages and the exposure of chondrocytes to the sequences they encode, either in soluble or more likely insoluble form, may therefore play a role in the excessive resorption of matrix molecules that is seen in arthritis and development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Matrix Biology - Volume 25, Issue 7, September 2006, Pages 419-429
Journal: Matrix Biology - Volume 25, Issue 7, September 2006, Pages 419-429
نویسندگان
Tadashi Yasuda, Elena Tchetina, Kunitaka Ohsawa, Peter J. Roughley, William Wu, Aisha Mousa, Mirela Ionescu, Isabelle Pidoux, A. Robin Poole,