کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2145569 1088798 2014 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tumour heterogeneity and the evolution of polyclonal drug resistance
ترجمه فارسی عنوان
ناهمگنی تومور و تکامل مقاومت دارویی پلی کلنال
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی

Cancer drug resistance is a major problem, with the majority of patients with metastatic disease ultimately developing multidrug resistance and succumbing to their disease. Our understanding of molecular events underpinning treatment failure has been enhanced by new genomic technologies and pre-clinical studies. Intratumour genetic heterogeneity (ITH) is a prominent contributor to therapeutic failure, and it is becoming increasingly apparent that individual tumours may achieve resistance via multiple routes simultaneously – termed polyclonal resistance. Efforts to target single resistance mechanisms to overcome therapeutic failure may therefore yield only limited success. Clinical studies with sequential analysis of tumour material are needed to enhance our understanding of inter-clonal functional relationships and tumour evolution during therapy, and to improve drug development strategies in cancer medicine.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Oncology - Volume 8, Issue 6, 12 September 2014, Pages 1095–1111
نویسندگان
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