PEA3 transcription factors are downstream effectors of Met signaling involved in migration and invasiveness of Met-addicted tumor cells

• Integration of the Met receptor signaling at the transcriptional level is poorly understood.
• In cancer cells harboring met gene amplification, expression of ETV1, 4 and 5 is dependent of the receptor activity.
• PEA3 factors are required for efficient migration and invasion mediated by Met, while other responses remain unaffected.
• The three PEA3 factors are key players of the Met signaling integration involved in regulation of migration and invasiveness.