Targeted tumor therapy by epidermal growth factor appended toxin and purified saponin: An evaluation of toxicity and therapeutic potential in syngeneic tumor bearing mice

► A 6900-fold enhancement in the in-vitro efficacy of targeted toxins. ► First report on usage of a purified saponin in-vivo as enhancer of targeted toxin-based tumor therapy. ► Reduced toxin dose with higher efficacy provides evidence for better translational research. ► Basis for testing in heterogenous tumor models and for numerous plant-derived toxins.