کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2145782 1088827 2010 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Targeted Therapies: The Rare Cancer Paradigm
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Targeted Therapies: The Rare Cancer Paradigm
چکیده انگلیسی

This review analyzes the state of the art of targeted therapies for several tumors, starting from the paradigmatic example of Imatinib treatment in chronic myelogenous leukemia (CML). We discuss how rare tumors can be models for various mechanisms of receptor tyrosine kinase (RTK) activation, and provide the opportunity to develop new therapies also for more common cancer types. We discuss the activation of the downstream RTK effectors as further targets for therapies in colorectal cancer. Finally, we highlight how a novel multidimensional approach which adds an in silico dimension to the in vitro and in vivo approach, can predict clinical results.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Oncology - Volume 4, Issue 1, February 2010, Pages 19–37
نویسندگان
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