کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2145856 1088833 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression and hypoxic up-regulation of neuroglobin in human glioblastoma cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Expression and hypoxic up-regulation of neuroglobin in human glioblastoma cells
چکیده انگلیسی

Neuroglobin is a recently identified globin molecule that is expressed predominantly in the vertebrate brain. Neuroglobin expression increases in oxygen-deprived neurons, suggesting it protects neurons from ischemic cell death. We report that neuroglobin transcript and protein are expressed in human glioblastoma cells, and that this expression increases in hypoxia in vitro. We also show that neuroglobin is up-regulated in hypoxic microregions of glioblastoma tumor xenografts. Our finding of hypoxic up-regulation of neuroglobin in human glioblastoma cells may provide insight into how tumor cells adapt to and survive in hypoxic microenvironments.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Oncology - Volume 3, Issue 1, February 2009, Pages 45–53
نویسندگان
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