کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2145953 | 1088840 | 2009 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Endocytic proteins in the regulation of nuclear signaling, transcription and tumorigenesis
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Endocytic proteins in the regulation of nuclear signaling, transcription and tumorigenesis Endocytic proteins in the regulation of nuclear signaling, transcription and tumorigenesis](/preview/png/2145953.png)
چکیده انگلیسی
Accumulating evidence argues that many proteins governing membrane sorting during endocytosis participate also in nuclear signaling and transcriptional regulation, mostly by modulating the activity of various nuclear factors. Some adaptors and accessory proteins acting in clathrin-mediated internalization, as well as endosomal sorting proteins can undergo nuclear translocation and affect gene expression directly, while for others the effects may be more indirect. Although it is often unclear to what extent the endocytic and nuclear functions are interrelated, several of such proteins are implicated in the regulation of cell proliferation and tumorigenesis, arguing that their dual-function nature may be of physiological importance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Oncology - Volume 3, Issue 4, August 2009, Pages 321–338
Journal: Molecular Oncology - Volume 3, Issue 4, August 2009, Pages 321–338
نویسندگان
Beata Pyrzynska, Iwona Pilecka, Marta Miaczynska,