کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2146553 1548357 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MicroRNA in lung cancer diagnostics and treatment
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
MicroRNA in lung cancer diagnostics and treatment
چکیده انگلیسی

MicroRNAs (miRs) are short RNA chains that regulate gene expression by inhibition of mRNA translation. Their expression is often deranged in cancer. Increasing evidence indicates that these molecules play an important role in oncogenesis and cancer progression. This review focuses on the clinical application of miRs in lung cancer, with the emphasis on detection of early lung cancer, prognostication and chemotherapy sensitivity prediction. Methodological aspects of studies on prognostic markers in early NSCLC are outlined in detail. Finally, modulation of miR expression in lung cancer as a therapeutic possibility is discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volume 717, Issues 1–2, 1 December 2011, Pages 25–31
نویسندگان
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