کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2146647 | 1548362 | 2011 | 6 صفحه PDF | دانلود رایگان |
Adaptive response (AR) and bystander effect are two important phenomena involved in biological responses to low doses of ionizing radiation (IR). Furthermore, there is a strong interest in better understanding the biological effects of high-LET radiation. We previously demonstrated the ability of low doses of X-rays to induce an AR to challenging heavy-ion radiation [8]. In this study, we assessed in vitro the ability of priming low doses (0.01 Gy) of heavy-ion radiation to induce a similar AR to a subsequent challenging dose (1–4 Gy) of high-LET IR (carbon-ion: 20 and 40 keV/μm, neon-ion: 150 keV/μm) in TK6, AHH-1 and NH32 cells. Our results showed that low doses of high-LET radiation can induce an AR characterized by lower mutation frequencies at hypoxanthine–guanine phosphoribosyl transferase locus and faster DNA repair kinetics, in cells expressing p53.
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volume 712, Issues 1–2, 1 July 2011, Pages 49–54