کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2146756 1548377 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanisms of dealing with DNA damage in terminally differentiated cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Mechanisms of dealing with DNA damage in terminally differentiated cells
چکیده انگلیسی

To protect genomic integrity living cells that are continuously exposed to DNA-damaging insults are equipped with an efficient defence mechanism termed the DNA damage response. Its function is to eliminate DNA damage through DNA repair and to remove damaged cells by apoptosis. The DNA damage response has been investigated mainly in proliferating cells, in which the cell cycle machinery is integrated with the DNA damage signalling. The current knowledge of the mechanisms of DNA repair, DNA damage signalling and cell death of post-mitotic cells that have undergone irreversible cell cycle withdrawal will be reviewed. Evidence will be provided that the protection of the genome integrity in terminally differentiated cells is achieved by different strategies than in proliferating cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Volume 685, Issues 1–2, 1 March 2010, Pages 38–44
نویسندگان
, ,